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Mots-c 10mg
Mots-c 10mg
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MOTS-c Peptide (Mitochondrial Open Reading Frame of the 12S rRNA-c)
For Research Use Only – Not for Human Consumption
Supplied by A2V Aminos and Peptides
Product Overview
MOTS-c is a mitochondrial-derived peptide consisting of 16 amino acids encoded by the mitochondrial 12S rRNA. It plays a significant role in regulating metabolic homeostasis, energy balance, and insulin sensitivity. Research has shown that MOTS-c can influence cellular metabolism by activating pathways involved in energy expenditure and mitochondrial function, making it of great interest in studies of metabolic diseases, aging, and exercise physiology.
Mechanism of Action
MOTS-c functions primarily by activating AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis. By stimulating AMPK and other metabolic pathways, MOTS-c enhances glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. It also influences nuclear gene expression to promote stress resistance and metabolic adaptation. These effects collectively improve energy metabolism and insulin sensitivity.
Research Applications
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Metabolic Regulation: Investigated for its ability to improve insulin sensitivity and glucose metabolism, relevant to diabetes and obesity research.
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Mitochondrial Function: Studied for promoting mitochondrial biogenesis and enhancing cellular energy production.
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Exercise Physiology: Explored for its potential to mimic exercise benefits and improve endurance and muscle function.
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Anti-Aging: Research focuses on MOTS-c’s role in mitigating age-related metabolic decline and promoting longevity.
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Stress Response: Examined for protective effects against metabolic stress and oxidative damage.
Peptide Stacking Considerations
MOTS-c is sometimes combined experimentally with peptides such as BPC-157 or Thymosin Alpha-1 to explore synergistic effects on metabolism, tissue repair, and immune function. These combinations are for research purposes only and should be handled cautiously.
Legal and Regulatory Status in Australia
In Australia, MOTS-c is classified as a Schedule 4 substance under the Poisons Standard, meaning it is prescription-only. It is not approved by the Therapeutic Goods Administration (TGA) for human use and is not listed on the Australian Register of Therapeutic Goods (ARTG). Possession or use without prescription is illegal. MOTS-c is supplied strictly for laboratory research. (tga.gov.au, aussiepeptides.com)
Product Specifications
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Purity: ≥98%
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Form: Lyophilized powder
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Available Sizes: 5mg and 10mg vials
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Storage: Store at 2–8°C short-term; freeze at -18°C or below for long-term storage. Protect from light and moisture. (australia.pharmalabglobal.com)
Reconstitution and Handling
Reconstitute the lyophilized MOTS-c with bacteriostatic water by injecting slowly down the vial side to avoid foaming. Gently swirl until fully dissolved, do not shake vigorously. Store the reconstituted solution refrigerated and use within 2–4 weeks.
Disclaimer
All products provided by A2V Aminos and Peptides are intended solely for laboratory research. They are not for human or veterinary consumption and should be handled by qualified professionals in compliance with applicable laws.
Note: This information is provided for research and educational purposes only and does not constitute medical advice. Consult a qualified professional before handling or using research peptides.

Structure of MOTS-C
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Molecular Formula: C101H152N28O22S2
Molecular Weight: 2174.64 f/mol
PubChem CID: 146675088
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